Metastatic colorectal cancers in the liver or lung showed a positive expression for DPD, OPRT, TS, TK, TP and dUTPase in 9% (3/35), 83% (29/35), 31% (11/35), 17% (6/35), 6% (2/35) and 57% (20/35) of cases, respectively (table 3). Here, TYMS is linked to colorectal cancer.