NFKB1 and Autoimmunity: Furthermore, the −169C/T SNP of FCRL3 has been shown to influence the level of FCRL3 expression on B cells through altering the binding affinity of the nuclear factor-kappa-B (NF-κB) [13], an important immunoregulatory factor, according to recent studies in both murine models and humans with diverse forms of autoimmunity [21].