The presence of a metabolic-like syndrome in GPRC6A−/− mice suggests that this receptor regulates metabolic pathways involved in glucose and fat metabolism, although these studies do not define the exact target organ of GPCR6A effects or whether this is a direct effect of GPRC6A or an indirect effect related to insulin resistance in GPRC6A−/− mice. The gene discussed is GPRC6A; the disease is Insulin resistance.