NFE2L2 and cancer: Nuclear factor E2-related factor 2 (Nrf2 or Nfe2l2) is indispensable to cellular defense against many chemical insults of endogenous and exogenous origin, which play major roles in the etiopathogenesis of many cancers and inflammation-related diseases such as inflammatory bowel disease and Parkinson’s disease (Nair et al, 2007a).