We also looked at microarray data from public repositories such as Oncomine (Rhodes et al, 2005), Gene Expression Omnibus (GEO), Public Expression Profiling Resource (PEPR), as well as data sets from the Kong Laboratory, to dissect the role(s) of key regulatory genes in these selected inflammation/cancer signatures and constructed a regulatory network for concerted modulation of Nrf2 and Nfkb1 involving several members of the MAPK family. This evidence concerns the gene NFE2L2 and cancer.