Many studies have implicated Nrf2 (Nfe2l2) in cancer (Ramos-Gomez et al, 2001; Katsuoka et al, 2005; Sporn and Liby, 2005; Nair et al, 2007a; Pearson et al, 2008) or inflammation-associated diseases such as colitis (Khor et al, 2006; Osburn et al, 2007), and Parkinson's disease (Clements et al, 2006), and NF-κB in inflammation (Muller-Ladner et al, 2002; Profita et al, 2008; Puthia et al, 2008) and cancer (Xu et al, 2005; Cilloni et al, 2006; Sun and Zhang, 2007; McDonnell et al, 2008). Here, NFE2L2 is linked to Parkinson disease.