Multivariate regression analysis indicated that uPAR mRNA high expression group in PB (relative risk (RR); 1.85, 95 % confidence interval (CI); 1.08–3.23, P=0.03) was an independent predictor for distant metastasis next to the incidence lymph node metastasis (RR; 6.50, 95 % CI; 2.99–15.77, P<0.0001) and depth of tumour invasion (RR; 28.2, 95% CI; 14.3–70.0, P<0.0001). Here, PLAUR is linked to neoplasm.