CXCL8 and ovarian neoplasm: However, recent in vivo studies using liposome-encapsulated siRNA oligonucleotides to target IL-8 expression has shown that targeting this chemokine reduces microvessel density and significantly enhances the antiproliferative effect of docetaxel on HeyA8 and SKOV3ip1 ovarian tumour growth (Merritt et al, 2008).