This method has also been used by Despriet et al [45] who reported increased risks of AMD in CFH risk genotype carriers with high C-reactive protein serum levels, elevated sedimentation rate (ESR), leucocyte count and smoking and more recently by Baird et al., [46] who demonstrated a G×E–interaction between a pathogenic load of C. pneumoniae and the CFH Y402H in the aetiology of AMD. This evidence concerns the gene CRP and age-related macular degeneration.