Previous work by our laboratory has shown that LG100268 (LG268), a ligand specific for RXR, inhibits IL-1β-induced MMP-1 and MMP-13 transcription in the SW-1353 human chondrosarcoma cell line and is associated with a decrease in histone acetylation proximal to the transcription start site in the MMP-1 and MMP-13 promoters [21]. Here, MMP1 is linked to chondrosarcoma.