Inparticular, celiac disease has been reported in association with severalprimary immunodeficiencies including isolated severe SIgAID [52, 53] or reducedIgA levels (20—<60 mg/100 mL) [20, 54, 55], panhypogammaglobulinemia [53] andisolated combined IgA and IgM deficiency [53].IgM deficiency has been more frequently reported—including 30 of 75 (37%) of adult cases, 5 of5 childhood cases [20], 11 of 30 (37%) untreated adult patients [54], 8 of 11untreated adult patients [55], 6 of 11 untreated, and 2 of 7 treated adultpatients [55]. The gene discussed is CD79A; the disease is immunodeficiency disease.