[1] However, the prevalence of those withdeficient but detectable levels of IgM is closer to 0.1–3.0% in hospitalized patients[1, 4, 5], 1.6%in an unselected community health screening [1, 6], 0.07% in an allergy andimmunology clinic [7], and 0.26% in an adult allergy and immunology clinic [8].There is a slightly higher penetration of SIgMID in males (1.97%) versusfemales (1.42%) [1]. The gene discussed is CD40LG; the disease is allergic disease.