Studies based oncatabolism and distribution of labeled IgM have not shown any difference indiet controlled untreated celiac disease [55].Where reported, SIgMID did not correlate with any specific biochemical,hematologic or histologic abnormalities.Jejunal biopsies of affected patients were no different than those ofceliac patients with normal immunoglobulin levels. The gene discussed is CD40LG; the disease is celiac disease.