THBS1 and neoplasm: Thegrowth of these cells into tumours could be suppressed by PPARα ligands inwild-type mice only, indicating that tumoursuppression by PPARα ligands was completely dependent on the expression of PPARα in the hostbut not in the tumour cells [48].Fenofibrate strongly induced the antiangiogenic factors TSP-1 and endostatin inwild-type, but not PPARα−/− mice, supporting the role of PPARα as an antiangiogenicregulator [48].