Todissect the mechanism by which PPARα suppressedtumour growth (i.e., direct effects on the tumour and/or angiogenesis), embryonicfibroblasts from PPARα (−/−) knockout mice were transformed with SV40 large T antigen andH-ras oncogenes then implanted into wild-type and PPARα−/− mice. This evidence concerns the gene PPARA and neoplasm.