In a recent report, Panigraphy et al.provide compelling evidence for PPARα inhibition oftumour growth by targeting angiogenesis [48].Similar to previous findings, PPARα activationhad direct effects on endothelial cells, inhibiting VEGF-induced endothelialcell migration in vitro and FGF2 induced corneal angiogenesis invivo [48].Tumour cell synthesis of VEGF and FGF2 was also suppressed by PPARα activation inconjunction with an increased expression of antiangiogenic thrombospondin-1(TSP-1) [48]. This evidence concerns the gene THBS1 and neoplasm.