This antagonistappears to act by promoting PPARβ/δ-mediated repression of gene expression.Unfortunately, this compound lacks invivo bioavailability, but will be a valuable tool for elucidating therole of PPARβ/δ in cancer andangiogenesis in vitro and a basis for further development ofa selective bioavailable PPARβ/δ antagonist [134]. Here, PPARD is linked to cancer.