AKT1 and neoplasm: PPARγ activation also restores PTEN expressionin tumor cells and thus blocks PI3K/Akt axis [38], it can also initiate a negativefeedback loop, which consists of calcineurin phosphatase, nuclear factor of theactivated T-cells (NFAT), and down syndrome critical region 1 (DSCR1), whichinhibits calcineurin and blocks NFAT activity necessary for proliferation andsurvival (see Figure 3(c)) [68], see Figure 4(c).