PPARγ is a potent modulator of the EC and VSMCfunction and inflammation: its effects on the tumor cells, tumor-associated MΦs (TAM), and tumor vasculature (EC andVSMCs) significantly attenuate tumor progression [3, 4], suggesting that PPARγ ligands may become new convenienttherapeutic modifiers targeting simultaneously tumors and their microenvironment[5]. This evidence concerns the gene PPARG and neoplasm.