In addition, PPARγ ligands cause NFκB transrepression, thus reducing the productionof inflammatory cytokines (IL-8, IL-6, MCP-1, and CX3CL1-1) by MΦs, and thus disrupting paracrine loopthat attracts tumor-associated MΦs (TAM) and thus stimulates angiogenesisand tumor growth [66], see Figure 4(c). The gene discussed is CXCL8; the disease is neoplasm.