The Arg80Gly (rs223019) polymorphism corresponds to the electrophoretically slow (Arg) and fast (Gly) forms of C3 and may be the causative polymorphism due to the fast forms probable involvement in other diseases including renal transplant survival, Chagas disease cardiomyopathy, and type II mesangiocapillary glomerulonephritis [31]–[33]. This evidence concerns the gene C3 and membranoproliferative glomerulonephritis.