Since we observed seizure activity in our mouse mutants, we examined with immunohistochemistry the expression of cholecystokinin (CCK), neuropeptide Y (NPY) and brain-derived neurotrophic factor (BDNF) in the HF of 8-week-old neo-excised SNAP-25b deficient mutants and WT littermates. This evidence concerns the gene BDNF and hydrops fetalis.