In conclusion, deletion of SNAP-25b results in dramatic alterations in neuropeptide levels in the HF, which together with increased levels of BDNF and DCx may provide an environment that promotes neuroprotection/neuroproliferation in response to disrupted synaptic transmission and seizure activity in neo-excised SNAP-25b deficient mutants. The gene discussed is BDNF; the disease is hydrops fetalis.