Immunohistochemistry revealed that spindle shape cells showed positive reaction for cytokeratins, vimentin, negative reaction for S-100 protein and desmin, squamous cell carcinoma-like nest forming epithelial components showed positive reaction for cytokeratins, both low- and high-molecular weight, negative for vimentin, S-100 and desmin. The gene discussed is VIM; the disease is squamous cell carcinoma.