TGFB1 and Tangier disease: With this in mind, we tracked in a NAFLD cohort the behaviour of serum TGF-β1, an indirect severity progression index, and ferritin, an ancillary marker for IR, correlating their concentrations to those present in chronic hepatitis C (CHC), disease characterized by the combination of apoptosis/inflammation and fibrosis, in which TGF-β1 and iron overload could play a key role too [9,10].