IQGAP1 and ovarian carcinoma: After 6 h-incubation, HO-8910PM-shIQGAP1 cells showed a significantly lower cell invasion activity as compared to HO-8910PM-shRNA negative and un-transfected HO-8910PM cells (Fig. 4b), suggesting that suppression of IQGAP1 decreases cell motility, therefore, supporting a important role for IQGAP1 in the metastasis of ovarian cancer cells [10].