LUM and breast carcinoma: Compared with women with no copies of the minor allele in LUM rs2268578, women with two copies showed the greatest risk for breast cancer in both the Mayo Clinic sample (OR = 2.2, 95% CI = 1.1 to 4.3; P2 df = 0.002) and the SEARCH study sample (OR = 1.4, 95% CI = 1.0 to 2.1; P2 df = 0.13).