In the present study, the observed risk associated with breast cancer from the LUM intronic SNP rs2268578 or from a SNP in strong linkage disequilibrium with rs2268578 may be consistent with increased protein expression of lumican in the study by Leygue and colleagues [11], if it represents a negative host response contributing to early tumor development through increased proteolysis or altered lumican deposition that precedes disorganized collagenous stroma [11]. The gene discussed is LUM; the disease is breast carcinoma.