LUM and breast cancer: Women with two copies compared with no copies of the minor allele in LUM rs2268578 were at higher risk, compared with control individuals, of ER-positive breast cancer in both the Mayo Clinic study (OR = 2.5, 95% CI = 1.2 to 5.3; P2 df = 0.001) and the SEARCH study (OR = 1.6, 95% CI = 1.0 to 2.5; P2 df = 0.10) (Table 6).