Of note, the three haplotypes in LUM that were associated with breast cancer risk had in common the G allele at position 2 (rs17714469) and a graduated change in the combination of alleles in the last three positions (rs2268578, rs10859110 and rs17018765) from GGA (haplotype 2a), associated with decreased risk, to AAA (haplotype 2h) and AAG (haplotype 2g), each associated with increased risk. This evidence concerns the gene LUM and breast cancer.