It has been reported that treatment with chemotherapeutic agents such as 5-FU and cisplatin induces up-regulation of SSAT expression in several cancer cell lines and N1, N11-diethylnorspermine, a polyamine analog, enhances cytotoxic effect of 5-FU and oxaliplatin along with up-regulated SSAT expression [33-35]. Here, SAT1 is linked to cancer.