IGF2 and neoplasm: This study also showed that P3 transcripts predominated in total IGF2 mRNAs in HB tumours irrespective of the IGF2 status (i.e., UPD, 11p15 loss, LOI or ROI); these findings were similar to those reported in foetal liver tissues showing elevated expression of IGF2 mRNA with predominance of the P3 transcript (Li et al, 1998a).