Significant microcephaly (OFC <−4 SD) alone can co-occur with normal intelligence in a number of settings—for example, Bloom syndrome (OMIM 210900), osteodysplastic primordial dwarfism due to pericentrin mutations (OMIM 210720), and autosomal dominant microcephaly (OMIM 156580).36 There are no reports of ASPM mutations associated with microcephaly and normal intelligence, and we found no examples of this in the families of this study. Here, ASPM is linked to microcephaly.