Our data on IGFBP-3 expression in melanoma do not strongly support a previously published report which found up-regulation of IGFBP-3 in melanoma metastases compared to primary melanoma specimens.[23] Our data indicates only a slight difference in IGFBP-3 expression between metastatic and primary tumors, and there was no significant difference in IGFBP-3 sera levels between metastatic and primary patients. Here, IGFBP3 is linked to melanoma.