IGFBP3 and neoplasm: It has been previously reported that low tumor expression of IGFBP-3 in patients with primary hepatocellular carcinoma was independently associated with poor survival.[32] Consistent with these data, high plasma levels of IGFBP-3 were shown to be predictive of longer progression-free survival in patients with advanced non-small cell lung cancer.[33] However, to our knowledge, no reports exist on the prognostic relevance of IGFBP-3 or -4 expressions in melanoma.