IGFBP7 and melanoma: [19,20,26] Wajapeyee et al recently described a novel function of IGFBPs in BRAF-mediated cellular senescence.[24] Specifically, data suggest that IGFBP-7 acts through a negative feedback loop to attenuate MAPK signaling, resulting in cellular senescence in BRAF mutant melanocytes and apoptosis in BRAF mutant melanoma cells.