Analysis of 507 ER-negative and 1,356 ER-positive breast cancer patients revealed that keratin-5 associated with ER-negative breast cancers (Figure 4a) in seven out of 13 datasets, and that Notch-1 associated with ER-negative breast cancers in nine out of 16 datasets (Table 2). This evidence concerns the gene NOTCH1 and breast carcinoma.