Intriguing, however, is that another developmental gene expression pathway (that is, Wnt/β-catenin) has been implicated in controlling survivin levels in intestinal crypt progenitor cells, potentially contributing to colon cancer [42], and that survivin expression been consistently associated with stemness gene signatures of mesenchymal [43], neuronal [44], and skin [45] progenitor cells. This evidence concerns the gene BIRC5 and colonic neoplasm.