NFKB1 and melanoma: These findings appear to lend support for our current observation and as such consistent with the role of genistein in the prevention of cisplatin-induced renal injury in mice [28], and its biological effects on breast [13], pancreas [27,29], and melanoma cells [30], associated with the inhibition in the translocation of p65 subunit of NF-κB in the nucleus, which is otherwise increased by the cisplatin treatment.