By adding the molecular markers to the base model, we found that the two marker combinations in the tumor tissue were identified as independent predictors: CyclinD1+/ErbB3+ (HR = 0.44, P = 0.034) and Ebp1+/Cyclin D1- (HR = 4.79, P = 0.003) (Table 4). This evidence concerns the gene ERBB3 and neoplasm.