As shown in Table 3, multivariate Cox regression analysis of all covariates focusing on DFS identified the following as independent significant prognostic factors: tumor size, p = 0.0347: lymph node metastasis, p = 0.0007: and cytoplasmic CXCR4 expression, p = 0.0465. Here, CXCR4 is linked to metastatic malignant neoplasm in the lymph nodes.