The majority of the genes in the signature are involved in processes associated with tumor growth such as DNA replication (BUB1, CCNB1, CENPA, ORC6L, RFC4, TK1), cell cycle control (BUB1, CCNB1, MYBL2, ORC6L, PKMYT1, RACGAP1), cellular assembly and organization (BUB1, CCNB1, CENPA, DIAPH3), and ubiquitination (UBE2S). Here, TK1 is linked to neoplasm.