Ang-1 concentrations in critically ill non-septic patients (0.8 ng/ml, 0.5 to 11.7 ng/ml), patients with severe sepsis (0.5 ng/ml, 0.3 to 18.8 ng/ml) and patients with septic shock (0.9 ng/ml, 0.3 to 5.5 ng/ml were markedly decreased compared with healthy controls (56.4 ng/ml, 34.5 to 71.3 ng/ml, p < 0.0001) (Figure 1a). This evidence concerns the gene ANGPT1 and Sepsis.