ANGPT2 and septic shock: In contrast, median serum Ang-2 concentrations were consistently increased in critically ill non-septic patients (2.8 ng/ml, 1.0 to 9.0 ng/ml), in patients with severe sepsis (16.45 ng/ml, 2.7 to 39.7 ng/ml) and patients with septic shock (28.1 ng/ml, 3.7 to 72.6 ng/ml), compared with healthy controls (0.9 ng/ml, 0.3 to 2.6 ng/ml; all p < 0.0001 versus controls) (Figure 1b).