That is to say that both MAT2A and MAT2β can facilitate liver cancer growth and it was interested to find that when MAT2A and MAT2β were suppressed by LV-siMAT2A and LV-siMAT2β respectively, apoptosis and growth-inhibition were both induced, LV-siMAT2A had no effect on expression of MAT2β and LV-siMAT2β had no effect on expression of MAT2A at either mRNA or protein levels. Here, MAT2A is linked to liver cancer.