LEP and hepatocellular carcinoma: It has been proved that βsubunit was associated with cirrhosis and cancer providing a proliferative advantage in hepatoma cells through its interaction with MATIIα2 and down-regulation of SAMe levels[4] Recently hepatocyte growth factor (HGF) which is necessary for regeneration of hepatic cell was found to promote proliferation of hepatoma cells by up-regulating the expressions of MAT2A and MAT2β at low density[5], leptin which was demonstrated to be mitogenic in human liver cancer cell lines HepG2 was also related with increasing expressions of MAT2A and MAT2β[6].