MYOC and open-angle glaucoma: However, the phenotype of transgenic mouse expressing the same mouse mutant myocilin [42] or human myocilin Y437H [23] in the presence of endogenous wild-type mouse myocilin, show phenotypic features similar to those of POAG in humans (i.e. moderate elevation of IOP, loss of approximately 20% of retinal ganglion cells in the peripheral retina, and axonal degeneration in the optic nerve).