Upregulation of Prox1 expression induces the progression of colon cancer [9] and the invasiveness of Karposi’s sarcoma [10] while the overexpression of Prox1 in blood endothelial cells induced their conversion to a lymphatic endothelial phenotype associated with upregulation of cell proliferation markers including PCNA, cyclin E1 and E2 [11]. The gene discussed is PROX1; the disease is malignant colon neoplasm.