CTSD and Parkinson disease: Although Ctsd-/- brain extracts exhibited increased immunoreactive protein species recognized by the anti-phospho-α-syn antibody that specifically recognizes human LB[36], α-syn accumulations in Ctsd-/- brains could not be detected by this antibody that specifically recognizes human LB despite that they were successfully used in our hands to demonstrate LB-specific staining of human PD specimen (data not shown).