Interestingly, as previously reported in a large multicentre retrospective study on histological material, well-differentiated thyroid carcinomas almost invariably express galectin-3 (>94% of all thyroid cancer types, with exclusion of the medullary carcinoma), while benign thyroid proliferations do not (only 2% of the benign nodules, mostly represented by adenomas, were galectin-3 positive) [10]. The gene discussed is LGALS3; the disease is thyroid gland carcinoma.