A recent report showed a possible role of c-KIT in subsets of melanoma, in particular, mucosal melanomas (21% KIT mutations, 61% c-KIT overexpression), acral cutaneous melanomas (11% KIT mutations, 75% c-KIT overexpression) and cutaneous melanomas on skin with chronic sun damage (17% KIT mutations, 100% c-KIT overexpression) (Curtin et al, 2006). This evidence concerns the gene KIT and cutaneous melanoma.