c-KIT protein expression could be observed in 91% of our primary mucosal melanomas, which is similar to the rates reported in other series of primary mucosal melanomas of the anal/rectal tract (12 out of 16 in Chute et al, 2006) and oral cavity (16 out of 18 in Rivera et al, 2008), respectively. This evidence concerns the gene KIT and mucositis.