The accumulation of p27 because of the inhibition of PI3K activity by LY294002, and its association with cell cycle arrest in the G1 phase have been shown in ovarian cancer, pancreatic ductal carcinoma and choroidal melanoma cell lines (Casagrande et al, 1998; Hu et al, 2000; Gao et al, 2004; Takeda et al, 2004). The gene discussed is CDKN1B; the disease is pancreatic ductal adenocarcinoma.