LEPR and breast carcinoma: The evaluation of the relationship of the LEPR Gln223Arg polymorphism and breast cancer risk showed that premenopausal women carrying at least one LEPR 223Arg allele were at a modestly increased risk of breast cancer (OR = 1.8, 95% CI 1.0–3.3, p = 0.05); the risk was unaltered after adjusting for waist/hip ratio and age (OR = 1.8, 95% CI 1.0–3.2, p = 0.07).