Since then, however, conflicting results have been reported by other investigators in terms of whether Rb gene alterations are specific for parathyroid cancer.(31–33) Moreover, Shattuck et al.(34) failed to detect microdeletions, insertions, or point mutations in the coding and promoter regions of the Rb gene in parathyroid carcinomas. Here, RB1 is linked to malignant tumor of parathyroid gland.