The gene is known now as HRPT2 but other terms have been used, such as CDC73 and Clorf 28.(22) Evidence points to a strong association between HRPT2 mutations, the gene responsible for HPT-JT, and parathyroid carcinoma.(35–37) Parathyroid carcinoma occurs with higher frequency in HPT-JT than in sporadic PHPT (15% versus <1%). The gene discussed is CDC73; the disease is parathyroid gland carcinoma.