CDC73 and malignant tumor of parathyroid gland: Moreover, the relatives of a patient with seemingly sporadic parathyroid carcinoma carrying a germline HRPT2 mutation are susceptible to the development of parathyroid cancer or other manifestations of HPT-JT syndrome.(43,44) In one such patient, a parathyroid cancer was imaged early by neck ultrasonography in an individual who had not yet become hypercalcemic.(43) Therefore, monitoring of family members with serum calcium determinations and neck ultrasonography is warranted.