GLA and hyperinsulinemic hypoglycemia, familial, 4: Fabry Disease (FD) is a rare genetic syndrome, with a classic X-linked alpha -galactosidase A (alpha -Gal A) deficiency phenotype; it has an estimated incidence of approximately 1 in 40,000 – 50,000 males, with recent epidemiologic evidence of later-onset variants [1].