PMP22 and Smith-Magenis syndrome: Prominent examples of inherited genomic disorders caused by NAHR include CMT1A and HNPP, caused by the recurrent duplication/deletion of a 1.4 Megabase (Mb) DNA fragment on chromosome 17p12; and sporadic genomic disorders include Potocki-Lupski syndrome (PTLS; MIM610883)/Smith-Magenis syndrome (SMS; MIM182290) caused by the reciprocal duplication/deletion on 17p11.2.