Studies in spontaneously hypertensive rats have confirmed that arterial pressure regulation is in part mediated by TRH [39]; similarly, polymorphic variants of genes such as the TSH receptor gene or the type 2 iodothyronine deiodinase genes could be implicated in both insulin resistance and the regulation of arterial pressure and TSH levels [40,41]. The gene discussed is TRH; the disease is Insulin resistance.