Cytoplasmic HIF-1α expression is more prominent in serous and endometrioid carcinoma, however this staining pattern is unexpected, since HIF-1α should translocate from the cytoplasm to the nucleus in order to activate its target genes within a short period of time, and accumulation of cytoplasmic HIF-1α should not be detected [20]. This evidence concerns the gene HIF1A and endometrioid adenocarcinoma.