HSP90AA1 and cancer: The heat shock protein 90-alpha (HSP90α) protein is referred to as the cancer chaperone [25,26], a molecular chaperone of proteins involved in essential signal transduction pathways regulating proliferation, differentiation, apoptosis, angiogenesis, metastasis, oncogenesis [27-29], genetic variation [30,31], invasion [32] and cellular transformation [33].