To investigate the role of MAPK in the induction of MUC2 and NF-κB by DCA in esophageal adenocarcinoma cells, we examined phosphorylation of ERK1/2, JNK, P38 kinases and total ERK1/2, JNK, P38 kinases after treatment of SEG-1 cells with 100 μM DCA for 18 hours. This evidence concerns the gene MAPK3 and esophageal adenocarcinoma.