Although regulations of MUC1 and MUC4 mucin genes by bile acids, such as DCA, CDCA and TCA, in human oesophageal cancer cells have been the thorough extensive study [14-16], the mechanisms responsible for regulation of MUC2 expression in the esophageal adenocarcinoma cells remain unknown. The gene discussed is MUC5AC; the disease is esophageal adenocarcinoma.