ESR1 and neoplasm: Similarly, the proportion of patients with ER-negative status (DMFS, P = 2.2 × 10-16; BCSS, P = 2 × 10-14), with HER2-positive status (DMFS, P = 8.5 × 10-5; BCSS, P = 0.0001), in the high-grade subgroup (DMFS, P = 2.2 × 10-16; BCSS, P = 2.2 × 10-16) and with a mean tumor size (DMFS, P = 0.0004; BCSS, P = 2.4 × 10-5) were all correlated to the number of times a sample was classified as poor outcome by the nine signatures.