SIRT1 and Hepatic steatosis: Taking into account that modest overexpression of SIRT1 leads to protection from high-fat diet induced hepatic steatosis in mice [8], our study let assume that the minor allele of rs12413112 may negatively affect SIRT1 expression, especially as the SNPs tagged by this intronic SNP, namely rs11599151, rs11599524 and rs12778366, are all located in the SIRT1 promoter.