MMP13 and osteoarthritis: Additionally, inhibition of miR-22 in osteoarthritic chondrocytes up-regulated PPARA (4.9 fold) and BMP7 (5.8 fold) expression, blocked the inflammatory process, through inhibition of IL1B (7.6 fold), inhibited catabolic changes such as MMP13 expression (7.9 fold) and activated the cartilage repair protein aggrecan (3.1 fold) (Figure 6B), suggesting the therapeutic potential of microRNA inhibition in osteoarthritis.