In this study we aimed to investigate whether any further alterations in either mitogenic (MAPK) or metabolic (PI3K/Akt) pathways downstream of insulin receptor can be detected in skeletal muscle in response to in vivo insulin stimulation that could explain why are LBW men at higher risk of developing insulin resistance and type 2 diabetes in later life. Here, AKT1 is linked to type 2 diabetes mellitus.