HIF1A and renal cell carcinoma: The role of pVHLin the regulation of hypoxia-inducible genes through thetargeted ubiquitinylation and degradation of hypoxia-inducible factor-1α (HIF1α) has beenelucidated, leading to a model of how disruption of the VHL gene results in RCC andthe production of highly vascularized tumors.