αGalCer has shown antimetastatic activity in various experimental tumor models (e.g., B16 melanoma, Lewis lung carcinoma, FBL-3 erytroleukemia, Colon26, and RMA-S 3LL tumor cells) in vivo [52–54].This effect of the compound was tested in CD1d−/−, Ja281−/− RAG−/−NKT mice, which have no iNKT cells and in NK-depleted wild-type mice. The gene discussed is CD1D; the disease is neoplasm.