It is anticipated that the model of TSST-1-induced inflammation, whichnecessitates the bridging of Vβ2-specific T cells and MHC class II moleculesbearing antigen presenting cells, will provide a useful means to study the role of HMGB-1 in T cell-monocyte interactions, Th1polarization, and the ensuing immune response leading to tissue injury.Finally, this study also provides a rationale to investigate thepotential to target HMGB-1 for therapy for inflammatory disorders induced byTSST-1, such as toxic shock syndrome, as it is currently being investigated forgram negative sepsis [9]. Here, HMGB1 is linked to Sepsis.