Further, a mild PCP phenotype was observed in Dvl2+/−;Dvl3+/− double heterozygotes, despite normal development in the single heterozygotes and the defect in Dvl2+/−;Dvl3−/− double mutants was much more severe than in the single Dvl3−/− mutant. The gene discussed is DVL2; the disease is pneumocystosis.